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However, the inhibition of -GCS activity by GSH is of physiological significance [7] and is the rate-limiting step in GSH biosynthesis

In line with the effect of LD on the collagen fibers, this group, later on, discovered that the MMP-2 protein expression was significantly reduced in rats treated with LD with an increased tissue inhibitor of metalloproteinase-2 (TIMP-2) expression, suggesting the influence of LD on the ECM (Wang et al., 2016)

Mechanical forces from different tissues are transmitted through membrane receptors, actin cytoskeleton, and nuclear envelope, thereby affecting gene expression within the cell nucleus

& Stampfli, R